肖宇婕

研究领域

（1）生物教育，科学教育；（2）神经退行性疾病病理机制与转化；神经调控干预情绪或运动障碍相关疾病的机制与转化；光学成像技术开发。

办公地址：北京市海淀区阜外白堆子甲23号bet36365路检测中心东一区

电子邮件：7227@cnu.edu.cn

教育背景

2011.09-2015.07，北京师范大学，生命科学学院，理学学士

2012.09-2015.07，北京师范大学，文学院，文学双学士

2015.09-2021.07，北京师范大学，脑与认知科学研究院，理学博士

工作经历

2024.12至今，bet36365路检测中心，bet36365路检测中心，教师

2021.08至2024.12，复旦大学，脑科学转化研究院/附属金山医院，博士后/助理研究员

教学工作

主要承担bet36365路检测中心“小学教育专业”科学方向本科生《生物学》课程的教学。

科研项目

2023.01-2025.12，国家自然科学基金青年项目，No.32200951，主持。

2022.09-2024.08，中国博士后科学基金面上资助（第72批），No.2022M720801，主持。

2016.01-2020.12，国家自然科学基金重点项目，中脑多巴胺神经元轴突结构和功能及其异常的机制研究，主要参加者（主持人：舒友生）

2017.01-2019.12，国家自然科学基金国际（地区）合作与交流项目，经颅直流电刺激的神经生物学机制，参与（主持人：舒友生）

国家自然科学基金青年项目，前额叶皮层神经元的轴突功能异常在精神分裂样行为中的作用，参与（主持人：米真）

上海市“科技创新行动计划”项目，深层光学功能脑成像新技术，参与（主持人：李博）

上海市面上项目，三光子显微镜的荧光收集光路设计优化及其在深层活体神经成像的应用，参与（主持人：李博）

学术成果

科研论文

1. Wu KM, Xu QH, Liu YQ, Feng YW, Han SD, Zhang YR, Chen SD, Guo Y, Wu BS, Ma LZ, Zhang Y, Chen YL, Yang L, Yang ZF, Xiao YJ, Zhao J, Chen SF, Cui M, Lu BX, Le WD., Shu YS, Ye KQ, Li JY, Wang J, Liu C*, Yuan P*, Yu JT*. ,Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease. Science. 2025. (IF 44.7/JCR1区TOP)

2. Zhao R#, Ren BH#, Xiao YJ#, Wei JF, Zou Y, Qi YQ, Hu AK, Huang Z. Josh, He M, Shu YS*, Lu JT*, Tai YL*. Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment. Science Advances. 2024. (#Co-author, IF 14.98, JCR1区)

3. Deng P, Liu SP, Zhao YG, Zhang XX, Kong YF, Liu LL, Xiao YJ, Yang SS, Hu JH, Su JX, Xuan A, Xu JH, Li HJ, Su XM, Wu JC, Mu Y, Shao ZC, Kong CH, Li B*. Long-working-distance high-collection-efficiency three-photon microscopy for in vivo long-term imaging of zebrafish and organoids. iScience. 2024. (IF 5.8, JCR1区)

4. Lin LY, Liu JX, Pang ZY, Pang W, Jiang XY, Lei M, Gao JC, Xiao YJ, Li B, Hu F, Bao ZZ*, Wei XB*, Wu WB*, Gu BB*. General Post-regulation Strategy of AIEgens’ Photophysical Properties for Intravital Two-photon Fluorescence Imaging. Advanced Science. 2024. (IF 14.60, JCR1区)

5. Wang DX#, Dong ZJ#, Deng SX#, Tian YM, Xiao YJ, Li XR, Ma XR, Li PX, Chang HZ, Li L, Han M, Wang F, Wu Y, Zheng SS, Gu HM, Zhang YN, Wu JB, Wu F, Peng YL, Zhan RY, Gao LX, Sun QM, Guo Xing, Zhao XD, Luo JH, Han L*, Shu YS*, Zhao JW*. GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21. Nature Communications, 2023. (IF 17.694, JCR1区)

6. Xiao YJ, Deng P, Zhao YG, Yang SS, Li B*. Three-photon excited fluorescence imaging in Neuroscience: From Principles to Applications. Frontiers in Neuroscience. 2023. (IF 3.7, JCR2区)

7. Wang X, Shu ZF, He QS, Zhang XW, Li LZ, Zhang XX, Li L, Xiao YJ, Peng Bo, Guo FF, Wang DH*, Shu YS*. Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection. Neuroscience Bulletin,2023. (IF 5.6, JCR1区)

8. Xue WW, Li B, Liu HH, Xiao YJ, Li B, Ren L, Li HJ, Shao ZC*. Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing. iScience. 2023. (IF 5.8, JCR1区)

9. Ma XR#, Zhu XD#, Xiao YJ, Gu HM, Zheng SS, Li L, Wang F, Dong ZJ, Wang DX, Wu Y, Yang CY, Jiang WH, Yao K, Yin Y, Zhang Y, Peng C, Gao LX, Meng ZX, Hu ZP, Liu C, Li L, Chen HZ, Shu YS, Ju ZY*, Zhao JW*. Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nature Communications, 2022. (IF 17.694, JCR1区)

10. Feng S, Zhang T, Ke W, Xiao YJ, Guo Z, Lu CL, Li ST, Guo ZX, Liu YY, Tan GH, Chen YY, Yue F, Shu YS, Yue CM*, Jing NH*. The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys. Life Medicine, 2022.

11. Xiao YJ, Yang J, Ji WL, He QS, Mao LQ*, Shu YS*. A- and D-type potassium currents regulate axonal action potential repolarization in midbrain dopamine neurons. Neuropharmacology. 2021. (IF 5.25, JCR1区)

12. Liu X#, Qiao Z#, Chai YM#, Zhu Z#, Wu KJ, Ji WL, Li DG, Xiao YJ, Mao LQ, Chang C*, Wen Q*, Song B*, Shu YS*. Non-thermal and reversible control of neuronal signaling and behavior by mid-infrared stimulation. PNAS. 2021. (IF 16.6, JCR1区)

13. Mi Z, Yang J, He QS, Zhang XX, Xiao YJ and Shu YS*. Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia. Front. Cell. Neurosci., 2019. (IF 6.147, JCR1区)

14. Yang J, Xiao YJ, Li L, He QS, Li M and Shu YS*. Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons. Front. Cell. Neurosci., 2019. (IF 6.147, JCR1区)

15. Wu R, Li A, Sun BF, Sun JG, Zhang JH, Zhang T, Chen YS, Xiao YJ, Gao YH, Zhang QY, Ma J, Yang X, Liao YJ, Lai WY, Qi XL, Wang SK, Shu YS, Wang HL, Wang FC*, Yang YG*, Yuan ZQ*. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research, 2019. (IF 44.1, JCR1区)

16. Jiang YB, Xiao YJ, Zhang XX and Shu YS*. Activation of axon initial segmental GABAA receptors inhibits action potential generation in neocortical GABAergic interneurons. Neuropharmacology, 2018. (IF 5.25, JCR1区)

专利

李博，赵耀光，任煜轩，肖宇婕.一种具有高效率荧光收集的多光子显微系统：中国，CN202123264431.3 [P]. 2021-12-23.

科普文章

肖宇婕，薛碧清，杨沙沙，李博，“多光子成像技术：解析大脑深部的利剑”，科学，74(04)，39-43，2022。